生物素标记的 BCMA 和单体 BCMA 蛋白
BCMA is selectively induced during plasma cell differentiation and is nearly absent on naive and memory B cells (Avery et al., 2003; Chiu et al., 2007). The interaction between BCMA and its ligand BAFF and APRIL is involved for the maintenance of long-lived plasma cells (O'Connor et al., 2004; Peperzak et al., 2013). Multiple BCMA-targeted therapies of B-cell derived malignancies are underdevelopment, including BCMA-targeting chimeric antigen receptor T (CAR-T) and GlaxoSmithKline's GSK2857916.
2801 人阅读发布时间:2017-02-04 10:36